Tracer-kinetic analysis of Gd-EOB-DTPA in the liver with a dual-inlet two-compartment uptake model
نویسندگان
چکیده
PURPOSE: Liver perfusion can be quantified from bolus-tracking MRI with an extracellular tracer and a dual-inlet onecompartment model [1]. The liver-specific contrast agent GdEOB-DTPA is taken up in the hepatocytes, and therefore has the potential to provide an additional and more direct measure of liver function [2,3]. The aim of this study is to develop and validate a tracer-kinetic model for bolus-tracking MRI with GdEOB-DTPA. In this first step, the model is evaluated in normal appearing liver tissue.
منابع مشابه
In-vivo evaluation of hepatic function using dynamic Gd-EOB-DTPA enhanced MRI with a dual-input one output two-compartment pharmacokinetics model
vein d) tissue; and e) the concentration profiles and fitted result. Fig.1: Schematic diagram of perfusion model, orange dots are Gd-EOB-DTPA In-vivo evaluation of hepatic function using dynamic Gd-EOB-DTPA enhanced MRI with a dual-input one output two-compartment pharmacokinetics model Jia Ning, Sheng Xie, Lei Wang, Hua Guo, Xihai Zhao, Chun Yuan, and Huijun Chen Center for Biomedical Imaging ...
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